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Platelet rich plasma therapy

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12 years 5 months ago #19506 by sem40
Platelet rich plasma therapy was created by sem40
I recently came across an article about the use of platelet rich plasma injections to cure torn muscles in athletes. There's controversy over whether or not the treatment works more than a placebo but I find it interesting that Dr.'s would even consider that platelets can be used for their healing properties. Dr's make it sound like all platelets do is clot blood. I'm in the ITP camp that has muscle/joint pain. If concentrated platelet injections are thought to be able to heal "Tiger Woods" "sore knee" than wouldn't there be the possibility that someone with a depleted amount of platelets may suffer increased muscle/joint pain/injury?

"In theory, the distilled growth factors (a protein or substance that helps stimulate growth) should speed healing and improve the tissue’s health, which has happened in the lab. When scientists surgically created lesions in animal tendons and other tissues, P.R.P. therapy nudged the injured tissues to rapidly create new collagen and blood vessels."


well.blogs.nytimes.com/2011/01/26/phys-ed-does-platelet-rich-plasma-therapy-really-work/?partner=rss&emc=rss

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12 years 5 months ago #19509 by eklein
Replied by eklein on topic Re: Platelet rich plasma therapy
I read up on this also and found it interesting. I have struggled for years with painful achilles tendonitis. Tendonitis is one of the problems this therapy might help. There seemed to be some reasonable results to suggest it could work. Your point is interesting, that if platelets in excess have a positive effect on certain healing, what effect might they have when there is a shortage?

I would guess that the micro-injuries we suffer through normal wear and tear might not heal as well if we have platelet shortages.
Erica

And she was!
Diagnosed May 2005, lowest count 8K.
4/22/08: 43K (2nd Rituxan)
10/01/09: 246K, 1/8/10: 111K, 5/21/10: 233K
Latest count: 7/27/2015: 194K

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12 years 5 months ago #19515 by Ann
Replied by Ann on topic Re: Platelet rich plasma therapy
Interesting. I have achilles tendonitis too.

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #19518 by Sandi
Replied by Sandi on topic Re: Platelet rich plasma therapy
I don't know. The end of the article states: "Most of the people in the latest studies did recover after receiving P.R.P., he pointed out, although no better than with other, cheaper injections. So if you’re undeterred by the expense, discomfort and questionable utility of P.R.P., the treatment may be worth the risk, when almost all else has failed." Doesn't seem all that reliable.

I then looked up the reason why platelets might aid healing and found this: "Platelets have "a whole host of growth factors that are responsible for the proliferative healing phase of an injury," Berkoff said."

www.wral.com/lifestyles/healthteam/story/7795081/

I'm always interested in what causes myalgias too, because I've had it for years now. The two things I keep coming up with are inflammation and lack of oxygen. Those reasons are totally different than injuries, so I don't know if growth factor would help in myalgia and joint pain situations. My platelet count has been in the 200's and 300's for years and that hasn't done a thing for my Lupus symptoms. I've seen just about every doctor there is from Rheumatologists to muscle specialists and every single one has told me there is nothing they can do that would benefit long term. I've tried just about everything.

I can tell you that heat helps, which supports the lack of oxygen theory since heat increases blood flow, which pushes more oxygen to the area. I also get Trigger Point Injections in my muscles (Pain Management Center), which are steroid shots. Those also help some, which supports the inflammation theory. High dose Prednsione also helps a lot.

I don't believe that ITP and chronic muscle and/or joint pain are directly related, but since autoimmunity and inflammation go hand in hand, some people may have a secondary disorder (such as MCTD). I do believe that during a period of low counts, an injury to muscles or tendons can occur that could cause miniscule bleeding in those areas that could cause pain, but it would most likely be local, not widespread.

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12 years 5 months ago #19522 by
Replied by on topic Re: Platelet rich plasma therapy
My older son had this done after a skateboard injury in which he tore his ACL (Anterior Cruciate Ligament of the knee).Reconstructive surgery was said to be the only solution by the orthopedist. But, since he was uninsured, the cost was prohibitive. A friend of mine who was a sports massage therapist suggested we look into Prolotherapy, as it had cured her of some very bad back and shoulder pain after a car accident, and later, a knee injury from skiing.

We went to the same Osteopath she had gone to, and I was surprised he had been doing it for nearly 25 years!
Though they never mention the term "Prolotherapy" in the above article, that's basically what they're talking about when they refer to the "cheaper injections" or the "placebo injections". My son had the regular Prolotherapy injections over a year's time, and I would say they were well worth the money, as they did put him out of pain. He had been at the point where he couldn't walk, had to be on crutches. After the very first injection, the doctor told him he wanted him to go walk around the block, and my son thought he was crazy! But, he got up and found that he could, with no pain. That first time, he probably overdid the activity at first, and the next day he was a bit sore.

But, after that , one series of shots would usually last him about 6 weeks, before he'd start getting sore again.
Because of the stories he'd read about, how painful the injections were, he was VERY apprehensive about trying it. But, once he did, it really wasn't too bad, especially as it only took 2 or 3 minutes for all 3 shots. (I think it was harder on me, watching it, as the needle is incredibly long! My son never watched it as that would freak him out a bit, too.) There were two times where the needle must have struck a nerve, and those were painful shots, and the pain remained both times until I gave him a dose of a homeopathic remedy called Ledum, which is a good remedy for painful injections. Both times, it worked to stop the pain within a few seconds. Hypericum would be another good remedy to try for that as well, as it's good for trauma to nerves. But, Ledum has more affinity for the joints.

The first 48 hours after a shot, you're supposed to rest and take it easy. Ideally, you want to have a pretty good inflammatory response, so there should be some swelling, stiffness and soreness in the joint. This is part of the healing response. The tendons and ligaments do not have a big blood supply, so this inflammatory response acts to bring a lot of blood flow and nutrients to the area. I guess some people have a big inflammatory response, which can be painful, but those are the people who usually heal the fastest. My son actually didn't seem to have much pain, nor inflammatory response, so his healing took longer. But, nevertheless, he definitely had some very positive results with it.

Then, for some reason, it seemed the shots stopped working as well. After a few months with very little improvement, and him being in pain again, his doctor told us about this new Platelet Rich Plasma therapy, how it was all cutting edge. In theory, it sounded like a great idea. Prior to that, the proliferant that was injected was basically a sugar water/saline solution. We saved up for that shot a long, long time, even though his doctor only charged him about a third of the usual cost, it was still a very expensive out-of-pocket expense. But, he said that one of the PRP shots would be equal to 3 to 5 of the regular shots, and he should heal faster. My son was one of the first patients to be treated with it in his office. Unfortunately, it seemed to have the oppoosite effect of what it was purported to do--it seemed to actually make my son's pain worse than it had been. We gave it time, but it never improved. After going back for another regular shot, and not getting any better, his doctor finally said he didn't think he could help him any further. It seemed like the PRP actually made his condition worse. Either that, or perhaps he simply had retorn the ligament after it had healed somewhat with the Prolotherapy. Guess we'll never really know. But, for us, the PRP was a huge disappointment, both because of the expense and the poor results.

My son was finally able to get the surgery he needed. The first ortho he was referred to was a horrible, horrible doctor, completely incompetent. Even though the MRI clearly showed that his ACL was now completely torn in two, when he went in for surgery, the doctor just left it like that, and instead, all he did was remove two egg-sized calcium deposits that were floating around in his knee capsule. Those had been causing a lot of his pain, but very obviously, being a young adult, he was also going to need the ACL repaired. Those calcium deposits were so big, now I wonder if maybe the PRP therapy had anything to do with making them get that large?

Finally got referred to a second opinion doc, who is fabulous. He did my son's surgery in April, and he's virtually back to normal, now. After being in a wheelchair or on crutches for over a year, the surgery has given him a new lease on life. For that we are eternally grateful. Because he has a history of head injuries and seizures, pain medications do not work well for him. So, I used only homeopathic remedies after the surgery, which is considered to be one of the most painful, and he never required anything else. In fact, his doctor and assistant say they have never seen anyone heal as fast as my son did.. They could not believe that he never needed any pain relief, either.
So, this was an instance where I found the two kinds of medicine complimented each other well.

So, really think if you want to try it, you might see just as good, if not better, results with the Prolotherapy only. It works best if the pain is from the tendon or ligament being overstretched or torn some, but not completely. If torn completely, the only option I know of is surgery. For Achilles tendonitis, homeopathically, we have only five remedies listed specifically for that: Cimicifuga, Ledum, Nux vomica, Rhododendron and Ruta. Who knows? One of them might help you. There are also numerous antibiotics and other medications that are known to have a bad effect on the achilles tendon, causing it to rupture. That's something else that should be looked at.

April

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2 weeks 2 days ago #73528 by oldstyle4o
Replied by oldstyle4o on topic Platelet rich plasma therapy
Hello,
My Background: 41 year old male

ITP 2008 - remission - Danazol and Rituxan worked.

2024 - Current - ITP came back - Danazol and Rituxan working well and praying for the same result - remission.

In regards to PRP for subjects in remission having had ITP or whom have low platelet numbers I would have to advise against it. Everyone is different but this is my story and I don’t want what happened to me to happen to anyone else.

In 2021 I had PRP to my right hip due to OA and hip pain. It worked great and my right hip feels great present day. So I used to be a proponent of PRP until recently.

2023-2024 I had right shoulder pain that would not heal. Tons of PT and still was not healing. I like the natural route of healing so I tried PRP and got (3) injections to my right shoulder. The injections are given once per week for (3) weeks. For those whom never heard of PRP essentially they draw blood from your arm and spin it in a centrifuge. The healing properties (platelets) are then injected into the problem area. After the last injection, approximately 7 days later, my ITP came back. Now with ITP it is very hard to pinpoint exactly that it was PRP that caused the return of my ITP but coincidentally it’s very hard for me to say that PRP isn’t the primary cause. I wish I had done a platelet count before I got the PRP injections but I did not. But I believe the PRP caused my body to go into overdrive and destroy my platelets. Two weeks ago I was down to 3 platelets. Fortunately now I am in normal range.

So this is my story. I was a proponent of PRP and now I am not. For those whom had ITP as a child, ITP as adult and are in remission, or have low platelets I would do your homework. God bless.

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