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Increased infections during 5 yrs before ITP

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9 years 8 months ago #52825 by Rob16
Increased infections during 5 yrs before ITP was created by Rob16
A large cohort study soon to be published shows that ITP patients had a roughly 9-fold increase in likelihood of having had infections requiring treatment, during the 5 years prior to ITP diagnosis, compared to non-ITP subjects. The infections observed were primarily candidiasis and virus infections. Treatments were disproportionately amoxicillin, macrolides, nitrofurantoin and antivirals.

One possible explanation for this is that ITP patients have a higher susceptibility to infection, even before the onset of ITP, implying an impaired immune system.

Another possible explanation is that the infections, or the medications used to treat them, are the cause of the ITP.

Increased susceptibility to infections before the diagnosis of immune thrombocytopenia
onlinelibrary.wiley.com/doi/10.1111/jth.13267/abstract

  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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9 years 8 months ago #52826 by mrsb04
Replied by mrsb04 on topic Increased infections during 5 yrs before ITP
An interesting theory
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9 years 8 months ago #52827 by Aoi
Replied by Aoi on topic Increased infections during 5 yrs before ITP
A similar correlation has been found in the onset of type-1 diabetes, and one book on the subject suggested that antibiotics may disrupt microbiome function, which in turn dysregulates immune function and in susceptible people leads to the onset of the disorder.
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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9 years 8 months ago #52829 by Sandi
Replied by Sandi on topic Increased infections during 5 yrs before ITP
I'd go with the second theory.

"Another possible explanation is that the infections, or the medications used to treat them, are the cause of the ITP."

I was rarely ever sick before ITP. I had bad colds once or twice a year, but that's it. The colds have actually lessened since I was diagnosed. Since I've been on immunosuppressants the past 10 years though, I get sick constantly, mostly bronchitis or pneumonia.
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9 years 7 months ago #53332 by Taz
Replied by Taz on topic Increased infections during 5 yrs before ITP
I find this very interesting. I would get sick with a child once or twice a year before ITP. Since ITP, I feel like I get every little thing. And I get it the worst or of everyone in our family. Granted, I now have young kids who breed germs, and that could play a role. But I've worked with children for over 15 years and have never been sick like I have this year and last.

Right now I have a bad sinus infection. My first ever. I'm miserable. I've had a fever for days. Started antibiotics yesterday after finally giving in. I am of course worried about my platelets, but I need relief.

Is it common for many people to get more illnesses after their diagnosis of ITP? I've never been treated for it, so I know it's not due to medications for it.
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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9 years 7 months ago #53334 by Sandi
Replied by Sandi on topic Increased infections during 5 yrs before ITP
No, I don't think it's common. Theoretically, it shouldn't cause more illness unless immunosuppressants are involved.
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9 years 7 months ago #53378 by cindyfrye
Replied by cindyfrye on topic Increased infections during 5 yrs before ITP
:( well maybe I do everything the hard way but I was hospitalized twice last year and on antibiotics three additional times for UTI. The hospitalization was for kidney failure. ITP didn't return until two weeks ago.

I tend to get stuff easily and more severely but don't take immunosuppressant but for ITP and 4 days in July for a bad gout flair.

Am ready to stay out of hospital a while.
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