Role of Polymorphisms in Idiopathic Thrombocytopenic Purpura: A Review

"The exact pathogenesis of ITP is unknown; potential causes range from inflammatory responses and reactions to single nucleotide polymorphisms that cause defective genomic changes.

Some disease states may cause substitution of nucleotides in the human genome, leading to an imbalance of T-helper-1 (Th1) and Th2 cells. Th1/Th2 imbalance may lead to an overproduction of inflammatory cytokines that can cause conditions such as ITP."

- By James Nam, PharmD for Oncology Nurse Advisor.

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