I've only been on Promacta for 7 months, and right now I'm on 50 mg a day to boost my platelets since they dropped to 16K this week. (I'm also on a difficult pred taper, currently at 6 mg/day.) The last time I was on 50 mg a day, my platelets went too high--so my hema prescribed 25 mg every other day. Eventually, I needed 25 EVERY day--and now up to 50/day. My hema had no hesitation in prescribing the every-other-day dosage. I gather this is not uncommon.
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