ITP Treatments

Dapsone

Dapsone (also called Diphenylsulfone, DDS, or Avlosulfon) is an anti-infective sulfone drug, commonly used to treat a form of dermatitis (herpetiformis) and susceptible cases of leprosy (Hansen’s disease). In recent years Dapsone has also proved useful in treating lupus, rheumatoid arthritis and as a second-line treatment for ITP. The exact mechanism by which Dapsone assists in ITP is unclear, however, limited studies report successful increases in platelet counts of around 40-50% of patients taking the drug.

Dosage

Dapsone is usually prescribed at between 25mg to 100mg per day. It takes an average of 3-4 weeks to effect platelet count. Regular blood counts should be performed to monitor potential hemolysis (red blood cell destruction and anemia). Liver function tests are also recommended.

Side Effects

Dapsone is generally well-tolerated despite its effects on red blood cells. Most side effects are dose-related and reversible.
Common: Hemolytic anemia (reduction in red blood cells), lowered hemoglobin (~1-2g), agranulocytosis (reduction in white blood cells), pale skin, fatigue.
Uncommon / rare: GI upset, headache, dizziness, tachycardia, nervousness, insomnia, skin disorders, muscle weakness, hypersensitivity phenomena (sulfone syndrome), mood changes, peripheral neuritis, male infertility.

Precautions

Dapsone is not recommended for people with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, severe anemia, methemoglobin reductase deficiency, or an allergy or sensitivity to sulfonamides. It is also unsuitable for those with liver or kidney problems, as well as pregnant women and nursing mothers.

ITP Treatments

Dapsone

Dosage

Side Effects

Precautions

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