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Clinical Trials

IMPORTANT!
Clinical trials listed for ITP are a starting point for discussion with a health care professional. Be sure you understand all the implications of the proposed treatment and read the informed consent very carefully before enrolling in a clinical trial.

List of Clinical Trials

Phase 3 Clinical Study with Investigational Drug "fostamatinib"
Rigel Pharmaceuticals Inc. is conducting a Phase 3 clinical study with an investigational drug, fostamatinib, for the treatment of patients with persistent or chronic ITP. If you are 18 years of age or older, have had a diagnosis of ITP for at least 3 months and have previously received at least 1 typical regimen for the treatment of ITP you may be eligible. There are a number of clinical trial sites already open in the U.S., Canada and Europe.

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Open-Label, Dose Escalation Study of PRTX-100 in Adults With Persistent/Chronic Immune Thrombocytopenia
Protalex, Inc., a clinical-stage biopharmaceutical company, is now enrolling patients in a Phase I/II open-label, dose-escalating study of PRTX-100 in adults with persistent/chronic ITP. Pre-clinical data indicate that PRTX-100 may have the potential to treat ITP by reducing the immune-mediated destruction of the platelets.

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What are Clinical Trials?

Clinical Trials are controlled patient studies that must be performed before a new drug or treatment is approved by the Food and Drug Administration in the US and similar organizations in other countries.  Clinical trials are also done after a drug or treatment is approved to document the effectiveness of the treatment or to gain approval to use the drug or therapy for a different disease or age group.

There are three main phases to clinical trials, done in sequence.  A Phase I study tests the safety and side effects of the drug.  A Phase II study is initiated to determine the efficacy of the drug, to see if it works as anticipated.  A Phase III study tests the efficacy of drug or treatment and documents the side effects in a large population of volunteers.

Finding a Clinical Trial

The best way to find the latest information on clinical trials is to visit ClinicalTrials.gov.  Pharmaceutical companies and researchers update this site frequently so it contains the most comprehensive and up-to-date clinical trial listings.  It features an easy-to-use search facility and detailed guidance for patients and industry.